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Liliana Gracias doctor dejemos este enigma a los
2018-10-25
Liliana: Gracias doctor, dejemos este enigma GDC-0994 los genetistas. Cirujana: ¿Acaso porque tenemos matriz? Liliana: Ya Paracelso la llamaba la matriz cósmica. Cirujana: Para Celso, además de un macrocosmos... Liliana: que es el universo. Cirujana: ...hay un microcosmos... Liliana: ...que es
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Despite scholars have examined various variables
2018-10-25
Despite scholars have examined various variables as well as their interrelationships to differentiate one life luliconazole stage from another, there is no agreement in the literature on either the time span for each stage, or the deterministic linkage or development of that stages (Galbraith, 1982;
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On the other hand controlling shareholders can elect
2018-10-25
On the other hand, controlling shareholders can elect their representative(s) to the board of directors who will appoint a manager that will act in their self-interest. Jensen and Meckling (1976) and Shleifer and Vishny (1986) demonstrate that controlling shareholders can impose greater monitoring o
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br Conclusion br Acknowledgments br Introduction A baumannii
2018-10-25
Conclusion Acknowledgments Introduction A. baumannii is a leading cause of nosocomial bacteremia, severe pneumonia, meningitis, infections of the urinary tract, bloodstream and other parts of the body. The emergence of sharply increasing rate of Multidrug-resistant A. Baumannii (MDRAB) infe
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Using the highly sensitive TCF Lef H
2018-10-24
Using the highly sensitive TCF/Lef:H2B-GFP reporter, we demonstrate that Wnt/β-catenin signaling is transiently active during muscle regeneration, specifically in myoblasts 1 dpi. Our finding that myoblasts transiently transduce Wnt/β-catenin signals agrees with previous analyses of nuclear β-cateni
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Due to the lack of reliable antibodies the
2018-10-24
Due to the lack of reliable antibodies, the homozygous knockout was verified by reverse transcription and qPCR analyses of different KLF15 locus regions. This revealed the anticipated absence of transcripts encoding for KLF15 (n=8 different passages). GAPDH was equally expressed and used for normali
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Overall our robust transcriptome data in cells undergoing hi
2018-10-24
Overall, our robust transcriptome data in Senexin A undergoing hiPSC reprogramming showed dramatic changes in cell signaling pathways, human-specific AS, and ASE during the progressive cell fate change of fibroblasts to iPSCs (Figure 6E). The data will broaden the knowledge of the reprogramming pro
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To determine whether the inhibition
2018-10-24
To determine whether the inhibition of p38 MAPK in activated huSCs could maintain their proliferative potential and prevent expression of genes for myogenic differentiation, we grew the glutathione s-transferase in the presence of a small molecule p38 inhibitor (p38i; SB 203580) and analyzed both t
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In the present study we present a step by
2018-10-24
In the present study, we present a step-by-step strategy by which gene-corrected osteopetrotic iPSCs were used to generate hematopoietic progenitor lgk974 able to give rise in vitro to functional osteoclasts, thus providing a proof of principle for an autologous cell therapy approach to treat osteop
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Taken together our findings suggest that in PD the
2018-10-24
Taken together, our findings suggest that in PD, the heterozygous GBA-N370S mutation leads to the misprocessing of GCase, ER stress upregulation, and autophagic/lysosomal dysfunction in dopaminergic neurons. We propose that this combination of disturbances impairs protein homeostasis in dopamine neu
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Rejection might also have occurred as iPSC CMs might fail
2018-10-24
Rejection might also have occurred as iPSC-CMs might fail to suppress recipient NK kisspeptin in MHC-matched transplantation. MHC class I molecules such as MHC-E, which are expressed on almost all cells in the body, bind to receptors on NK cells to inhibit cytotoxic activity and, following the immu
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Introduction The role of chromatin status
2018-10-24
Introduction The role of chromatin status on DNA damage response (DDR) and DNA double-strand break (DSB) repair has been extensively investigated in differentiated non-stem and cancer cells. Chromatin structure and remodeling plays an important role in the recruitment/assembly of repair factors and
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Another interesting finding of this study is
2018-10-24
Another interesting finding of this study is that bone formation in calvarial defects implanted with scaffolds laden with BMSCs pretreated with bone marrow extract is noticeably less than that in defects implanted with scaffolds laden with BMSCs pretreated with or without LCN2 and PRL. However, the
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When we compared the in
2018-10-24
When we compared the in vivo MaSC activity using the gold standard mammary fat pad transplant assay, we found the CD24+ CD49fhi SCA-1neg cells had higher stem cell activity than the CD24+ CD49fhi SCA-1+ subset. Although the stem cell activity of the CD24+ CD49fhi SCA-1+ cells was limited (in vitro m
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Introduction Open chromatin is a global constitutive feature
2018-10-24
Introduction Open chromatin is a global, constitutive feature of naive embryonic stem ON-01910 (ESCs), which are characterized by low levels of repressive histones and DNA methylation (Gaspar-Maia et al., 2011; Meshorer and Misteli, 2006). Diverse factors are required to maintain ESC chromatin in
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