• Using ESNPs to repair damaged tissue in neurodegenerative di

  2018-10-20

  

  Using ESNPs to repair damaged tissue in neurodegenerative diseases is an attractive option, as these ligand gated channels are more readily obtained than fetal material. Recent work on the relationship between neural stem cells and blood vessels (reviewed in (Bjornsson et al., 2015) as well as our

• CD A KLS cells express

  2018-10-20

  

  CD11A KLS induced pluripotent stem cells express multiple markers of endothelial cells (EPCR, VE-cadherin, and CD34), suggesting that they are recently derived from the endothelial lineage and raising the question of whether they retain endothelial cell potential and contain hemogenic endothelium.

• Introduction The vasculature is a multicellular system in

  2018-10-20

  

  Introduction The vasculature is a multicellular system in which each cell type plays an important and indispensible role in its function. The inner lining of endothelial cells (ECs), which are in direct contact with the blood, is surrounded and supported by perivascular cells—either vascular smooth

• Asiaticoside Finally we cultured hiPSCs according to

  2018-10-20

  

  Finally, we cultured hiPSCs according to the present strategy with some modifications (Figure 4A; Supplemental Experimental Procedures). hiPSCs formed colonies on day 0. In the mesoderm induction phase, these colonies were disrupted, but the Asiaticoside generated some clusters upon CHIR and Cyc tr

• In this paper we present an

  2018-10-20

  

  In this paper, we present an all-in-one platform, Pulse, which uses video microscopy and image-analysis algorithms (Maddah and Loewke, 2014) to automatically capture and quantify the beating patterns of cardiomyocytes. Our technique generates a beating signal that corresponds to the biomechanical co

• The trend for increased differentiation in the field is

  2018-10-20

  

  The trend for increased differentiation in the field is paralleled by a large and increasing proportion of papers in which both cell types are being used. To analyze the validity of the “gold standard” argument that is frequently used to justify the continued use of hESCs in research, we analyzed th

• In Stevens and colleagues found penta snRNP which contains a

  2018-10-20

  

  In 2002, Stevens and colleagues found penta-snRNP, which contains all five spliceosomal snRNAs and over 60 pre-mRNA splicing factors, in yeast. They proposed that penta-snRNP associates prior to pre-mRNA substrate binding rather than with the pre-mRNA based on the results of a stepwise addition of d

• In this work we developed

  2018-10-20

  

  In this work, we developed multiple tools to interrogate this autocrine and paracrine signaling loop involving α-5 laminin production by hPSCs. The use of the inducible short hairpin lines allowed us to control the dynamics of α-5 laminin production in a reversible manner. However, the interpretatio

• Here we study the impact of the

  2018-10-20

  

  Here we study the impact of the common GBA-N370S mutation on the phenotype of patient-specific dopaminergic neuronal cultures differentiated from iPSC lines derived from patients with PD and identify deficits in protein homeostasis. Our results suggest that the heterozygous GBA-N370S mutation leads

• Nishi et al a b have developed a method of

  2018-10-20

  

  Nishi et al. (2014a, 2014b) have developed a method of inducing cancer stem-like ceramidase (CSCs) through the reprogramming and partial differentiation of the immortalized but otherwise normal MCF10A human mammary epithelial cell line. To experimentally test our computational model of oncometaboli

• Generation of new cells during kidney repair has

  2018-10-20

  

  Generation of new cells during kidney repair has long been assumed to result from proliferation of surviving terminally differentiated cells. However, much of the modern evidence has used lineage tracing such as Six2 (Humphreys et al., 2008) or a terminally differentiated marker (such as the proxima

• The pituitary gland is considered the master

  2018-10-20

  

  The pituitary gland is considered the master gland of hormone function. Hypopituitarism is a disease condition with insufficient or absent function of the pituitary gland. Pituitary tumors are the most common cause but many other triggers can induce pituitary dysfunction including inborn genetic def

• Among the epigenetic aberrations of iPSCs

  2018-10-20

  

  Among the epigenetic aberrations of iPSCs, DNA methylation is of particular importance. Previous studies showed that unique de novo differentially methylated (DMR) or hydroxymethylated regions (hDMR) are present in iPSCs compared with hESCs (Lister et al., 2011; Wang et al., 2013). Furthermore, the

• Whether LIF contributes to differentiation inhibition in rab

  2018-10-20

  

  Whether LIF contributes to differentiation inhibition in rabbit PSCs is unclear. LIF and FGF2 cooperatively support self-renewal in ESCs derived from parthenogenotes and propagated in feeder-free conditions, but the effect of LIF is modest (Hsieh et al., 2011). In this study, AKSL and AKSgff cell li

• Pitavastatin a hydroxy methyl glutaryl coenzyme A HmG

  2018-10-20

  

  Pitavastatin, a 3-hydroxy-3-methyl-glutaryl-coenzyme A (HmG-CoA) reductase inhibitor, was cytotoxic only to undifferentiated NPCs, whereas another HmG-CoA reductase inhibitor, cilastatin, had no effect. Similarly, 5-FU was substantially more toxic to undifferentiated cultures and resulted in nearly

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