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The effects of these steroids namely the
2021-11-02
The effects of these steroids, namely the decrease in the peak and acceleration of desensitization could be observed in IGly activated by 100 μM glycine (concentration close to EC50). However, with an increase in glycine to 500 μM (a concentration close to saturating), the effect of steroids on the
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Because sleep and metabolism are intimately linked
2021-11-02
Because sleep and metabolism are intimately linked, the authors next move to study whether Eaat2 also controls metabolic rate. First, we must ask how sleep and metabolism are connected at a functional level. The BEC australia allocation hypothesis of sleep posits that organisms temporally partition
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br Treatment KD is currently the treatment of choice for
2021-11-02
Treatment KD is currently the treatment of choice for GLUT1-DS. It is a high-fat, carbohydrate-restricted diet that mimics the metabolic state of fasting; so, the KD relies an exogenous rather than body fat for ketone production, thus maintaining ketosis without weight loss. As the developing br
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br Introduction Glucose is the major carbon
2021-11-02
Introduction Glucose is the major carbon source in most organisms. Cancer L-a-Hydroxyglutaric acid disodium salt synthesis in particular require a steady source of energy to maintain growth and proliferation, and preferentially use glycolysis for their energy supply even under aerobic conditions
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In this study an galactosidase gene GalA from
2021-11-02
In this study, an α-galactosidase gene, GalA, from a Aspergillus oryzae strain RIB40 [14] was artificially synthesized. To produce high levels of secretory expression in Pichia and facilitate its industrial application, we systematically investigated the gene dosages and the role of the ERSAs, namel
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Although several new elements i e microsomes and NADPH were
2021-11-02
Although several new elements (i.e., microsomes and NADPH) were added in E. coli cultures in the current study, the concentration of LacZ gene inducer, IPTG, to stimulate for the maximum production of β-galactosidase enzyme at media pH of 7.0 was observed to be the same as in the previous study (Fig
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Recently some researchers working in
2021-11-02
Recently, some researchers working in China Pharmaceutical University developed novel FFA1 agonists some of which were found to be efficacious in the management of type 2 diabetes and with low toxicity. For instance, Zheng et al. [48] in their in vivo study using experimental animals, reported that
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Compound and several additional FPR antagonists identified h
2021-11-02
Compound 10 and several additional FPR1 antagonists identified here specifically blocked fMLF-induced responses mediated via FPR1 in FPR1-HL60 colorimetric australia and human neutrophils, but not responses mediated via FPR2 or FPR3 (in human neutrophils and transfected HL60 cells) or Fpr1 (murine n
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br FGF FGFR pathway as
2021-11-02
FGF/FGFR pathway as predictive factor Several studies have identified FGFR1 amplification as the major predictive factor of response to FGFR inhibitors [26], [27]. However, in a recent study on lung cancer cell lines with ponatinib, FGFR1 mRNA and protein expression, together with FGF2 and FGF9 m
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Due to the presence of all FGFRs in
2021-11-02
Due to the presence of all FGFRs in the epithelium, there are several FGFs ligands that could be binding to these FGF receptors, namely FGFs 1–4, 8–10, 16 and 18–20. By evaluating the known roles of FGFs in epithelial-mesenchymal interactions and in bone development, this list can be reduced. For ex
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br Conclusions and perspectives In conclusion offering duly
2021-11-02
Conclusions and perspectives In conclusion, offering duly validated and highly performing assays for measuring DiXaIs in plasma is a step, but not the final issue. More dedicated and individual assays will continue this innovative development, which witnesses the need for collaboration between co
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In the FARM motifs of
2021-11-02
In the FARM motifs of GGPPSs, hydrophobic AMN-107 receptor are replaced by aliphatic amino acids, which are more flexible residues and allow the entrance of longer substrates into the pocket (Wang and Ohnuma, 2000). It has been reported that the lepidopteran Manduca sexta CA possesses GGPP synthase
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Recent findings of us suggest that compounds that inhibit
2021-11-01
Recent findings of us suggest that compounds that inhibit both FAAH and TRPV1 may be more efficacious in pain relief than those targeting only one such protein. As continuation of our efforts to identify new molecules able to target simultaneously both FAAH and TRPV1 receptors, we hypothesized that
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As preclinical toxicity and efficacy both
2021-11-01
As preclinical toxicity and efficacy both appear to be associated with GlyT1 inhibition, it remains to be determined whether on-target toxicity can be separated from efficacy. The present study evaluated a series of GlyT1 inhibitors for target potency, mode of inhibition, residence time, activity in
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ICH induced striatal lesion produced a reduction of EAAT exp
2021-11-01
ICH-induced striatal lesion produced a reduction of EAAT1 expression analogous to the decreased glutamate uptake at 6 h. The combined reduction of excitatory amino Rocilinostat receptor transporters and of glutamate uptake activity might explain the well-known glutamate excitotoxicity following brai
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