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In SLO permeabilized human sperm the
2019-12-13
In SLO-permeabilized human sperm, the AR elicited by calcium, persistently active Arf6 [41] and Rab3A, 8-pCPT-2′-O-Me-cAMP [8], diacylglycerol and a non-hydrolyzable analog [35], is sensitive to the PLC blocker U73122. Furthermore, 8-pCPT-2′-O-Me-cAMP elicits a calcium signal in non-permeabilized sp
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8-Methoxypsoralen The H E staining and Nissl staining result
2019-12-12
The H&E staining and Nissl staining results showed that damage to the pyramidal neurons in the CA1 and CA3 regions of the hippocampus were observed in the 50 mg/kg/day DBP group, accompanied by an absence of Nissl bodies, suggesting that DBP exposure can lead to pathological changes in the neurons o
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ATP binding cassette transporters such as
2019-12-12
ATP-binding cassette transporters such as ABCA1 and ABCG1 are expressed on cell membranes to transport cholesterol from DMPO to HDL. These transporters help to improve RCT and reduce atherosclerosis. ABCA1 and ABCG1 gene expression are primarily induced by the stimulation of liver X receptor/retino
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In order to evaluate the in vivo pharmacology
2019-12-12
In order to evaluate the in vivo pharmacology associated with EP receptor antagonism, we wished to discover antagonists presenting a higher degree of selectivity over the other prostanoid receptors. We also wanted to increase the brain–blood ratio since it is probable that centrally mediated EP agon
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SB 242084 br Acknowledgments The research in this study was
2019-12-12
Acknowledgments The research in this study was supported by grants from CMHS, UAE University and Qatar University. The authors gratefully acknowledge Dr. R Lukas (Barrow Neurological Institute, Phoenix, AZ, USA) for SH-EP1 SB 242084 stably expressing the human α7 nACh and human α4β2 nACh recepto
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Introduction Fish commonly employ pheromones to regulate a
2019-12-12
Introduction Fish commonly employ pheromones to regulate a variety of functions including reproductive communication [1]. Reproductive pheromones induce both primer effects, such as changes in the endocrine or physiological state of conspecifics, and releaser effects such as rapid behavioral respon
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The genes corresponding to TVAG TVAG TVAG TVAG
2019-12-12
The genes corresponding to TVAG_263740, TVAG_487600, TVAG_282090, TVAG_170370, and TVAG_148010 seem to be the less expressed, and undetectable by proteomics approach. In comparison, in other T. vaginalis strains, and experimental conditions, they show very few or null EST\'s reports [4]. Concludi
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Multiple protein species are known to naturally
2019-12-12
Multiple protein species are known to naturally exist for the transmembrane receptors DDR1 and DDR2. Five splice variants have been characterized for DDR1 (“a” through “e”). The d and e isoforms lack the intracellular kinase domain of DDR1. The splicing of DDR1 to various extents has been reported i
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br Materials and methods br Results br
2019-12-12
Materials and methods Results Discussion In this study, we confirmed the activation of Akt by udenafil in 3T3-L1 cells. To elucidate the underlying mechanism of udenafil, we focused on the mitochondria. Our findings demonstrated that udenafil improved mitochondrial function and expression o
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br Funding This work was supported by the
2019-12-12
Funding This work was supported by the National Natural Science Foundation of China (grant number 81671411); Beijing Natural Science Foundation (grant number 7162062); Beijing Nova Program Interdisciplinary Cooperation Projects (grant number Z161100004916045); Beijing Municipality Health Technolo
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In the present study we
2019-12-11
In the present study, we identified that SDF-1α could significantly elevate the expression of p-P65 in the NF-κB signaling pathway and p-Akt in the PI3K-Akt signaling pathway, while significantly reducing the expression of p-IκB in the NF-κB signaling pathway. AMD3100 and hesperidin antagonized the
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br Results br Discussion GPCRs
2019-12-11
Results Discussion GPCRs recognize a broad range of molecules with a vast chemical PF-CBP1 hydrochloride through different mechanisms. Our understanding of the recognition of lipid mediators by GPCRs primarily comes from the structural studies of receptors for lysophospholipids and endocannab
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During the Lapita period in Tonga the Talasiu site would
2019-12-11
During the Lapita period in Tonga, the Talasiu site would have been an attractive location for human settlement as it overlooked an embayment holding large numbers of sessile and gregarious shellfish close to a fresh water solution channel, with gardening soils immediately inland. However, sea leve
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The proposed FDIR technique is
2019-12-11
The proposed FDIR technique is presented in the following format: Section 2 contains a survey of typical orbits of interest with regard to the U 18666A environment found in them, which is contrasted with a LEO orbit. Additionally, how the requirements for the satellite system can be estimated is pr
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There is an opposite opinion indicating that EphB plays a
2019-12-11
There is an opposite opinion indicating that EphB plays a role as cancer suppressor. Batlle et al. showed that loss of EphB expression represented a critical step in CRC progression, and CRCs that lacked EphB2 expression have been correlated with more advanced tumour stage, poor differentiation, and
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