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RCT pathway plays a critical role in the maintenance of
2019-08-16
RCT pathway plays a critical role in the maintenance of cholesterol homeostasis by facilitating the cholesterol clearance and cholesterol efflux (Levinson & Wagner, 2015). In the process of RCT, ABCA1 and ABCG1 played as crucial regulators in cholesterol efflux (Yasuda et al., 2011). Compared with h
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br Acknowledgments br Introduction Ubiquitin ligases limit t
2019-08-16
Acknowledgments Introduction Ubiquitin ligases limit the stability and activity of substrates by targeting them for proteasomal-dependent degradation. Siah is a two-member family of ubiquitin ligases implicated in control of key cellular processes. Among those, Siah ligases control prolyl hydr
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The lack of robust immunocompetent animal models permissive
2019-08-16
The lack of robust immunocompetent animal models permissive for HCV makes it hard to assess if the quantity and quality of vaccine-induced immunity is sufficient to confer protection. Thus, it is difficult to predict to what extent antibody responses induced by current vaccination approaches, includ
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br Conclusion The role of
2019-08-16
Conclusion The role of DNA-PK target in DNA DSB repair renders this ABT-737 powder kinase of great medicinal interest in cancer chemotherapy especially the cancer types of linked to DNA defects. Due to the absence of 3D DNA-PK target structure, different ligand-based methods were applied for desi
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An even more striking difference is observed when comparing
2019-08-16
An even more striking difference is observed when comparing active site residues, which are evolutionarily very well conserved in other soluble PPases 18, 19. In 31 known PPase sequences, 13 functionally important active site residues are conserved in all sequences, but only two of them (D70 and D97
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Compound was generated using a literature procedure and requ
2019-08-16
Compound was generated using a literature procedure and required two-step Dess–Martin-periodinane/Pinnick oxidation prior to the methylation of the sulfonamide. Compound () was obtained from the Suzuki coupling of the methyl ester intermediate (en route to LX7101 HCL ). Hydrolysis of all methyl este
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br System description and data collection Fig shows the
2019-08-16
System description and data collection Fig. 1 shows the arrangement of the system studied. It provided cooling Epothilone B to maintain thermal conditions in an institutional building. The locations of the measured variables (, and ) relating to temperature and flow rate are indicated in Fig. 1.
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The second part of this
2019-08-16
The second part of this study evaluated the role of CK1 in the eFABP4 cellular uptake in endothelial cells. By blocking CK1 expression using a specific siRNA, we corroborated that the presence of CK1 was fundamental for FABP4 cellular uptake and internalization in endothelial cells, thus decreased m
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br Experimental Procedures br Acknowledgments br Introductio
2019-08-15
Experimental Procedures Acknowledgments Introduction The ability of the affiliative and nurture hormone oxytocin (OT) to attenuate stress has been observed across psychological, neurological, and physiological levels [1], [2]. We and others have demonstrated that, in the gut, OT can lessen
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MM-102 Besides EGFR other tyrosine kinase receptors are
2019-08-15
Besides EGFR, other tyrosine kinase receptors are currently gaining attention as potential therapeutic targets. Included among these is the fibroblast growth factor receptor (FGFR) family, which is involved in the progression of a variety of cancers.7, 8, 9, 10, 11 In lung cancer, fibroblast growth
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br Methodology To simulate chip
2019-08-15
Methodology To simulate chip flow trajectory, the force and torque acting on the chips in high pressure coolant are computed based on the control volume method [6]. During the setup, a typical gun drill chip and gun drill bit are imported into ANSYS CFX 14.0 and prescribed as stationary solids. T
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Two parameters were extracted from these experiments to
2019-08-15
Two parameters were extracted from these experiments to compare the interactions of the three compounds with ct-DNA. The association constant K for the binding of the naphthalimide derivatives to ct-DNA was calculated by fitting the evolution of the fluorescence spectra with a 1:1 binding model usin
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br Materials and methods br Results br
2019-08-15
Materials and methods Results Discussion Structural analysis of dnmt3 sequences of different ploidy fish cloned in this study showed high similarities to zebrafish sequences, which also contained a unique N-terminal motif and a calponin homology (CH) domain, a conserved proline-tryptophan-t
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Different types of environmentally induced antinociception h
2019-08-15
Different types of environmentally induced antinociception have been reported in a wide range of species (e.g., Behbehani, 1995, Bolles and Fanselow, 1980, Harris, 1996, Millan, 2002, Rodgers, 1995). According to Bolles and Fanselow (1980), fear and pain are independent and competing motivational sy
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The significant CRF increase in the DS
2019-08-15
The significant CRF increase in the DS and the overall changes in the CRF system observed in the VM and DS during the development of sensitization suggest that this neuropeptide (and possibly urocortin) contributes to the specific molecular alterations occurring in the mesolimbic pathway that suppor
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