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Introduction Cysteinyl leukotrienes CysLTs LTC LTD and LTE a
2019-07-09
Introduction Cysteinyl leukotrienes (CysLTs), LTC4, LTD4 and LTE4, are 5-lipoxygenase pathway metabolites of arachidonic Progesterone of and deeply involved in bronchial asthma via activation of CysLT1 receptors [1], [2]. Specific CysLT1 receptor antagonists, including pranlukast [3], [4] and mont
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Although several examples of selective reduction of diazoest
2019-07-09
Although several examples of selective Sorbitol weight of α-diazoesters to α-hydrazonoesters have been described in the literature, reports on practical and general examples of such a process are scarce. In this context, there was a need to devise a mild and general method for the selective reducti
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Ketorolac Previous studies have indicated that
2019-07-08
Previous studies have indicated that hSSB1 may be phosphorylated at threonine residue 117 (T117) [13] and acetylated at lysine residue 94 (K94) [15], both of which promote hSSB1 function in response to ionising radiation exposure. Mass spectrometry screens of proteins immunoprecipitated with phospho
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br Additional CDKs with a role in cancer br Small
2019-07-08
Additional CDKs with a role in cancer Small molecule CDK inhibitors The majority of protein kinase inhibitors developed to date are type I inhibitors: they bind at the ATP–binding site, are ATP-competitive and target the kinase in its active state; with the activation loop DFG motif in the ‘in
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It has been reported that NMDA receptor hypofunction upregul
2019-07-08
It has been reported that NMDA receptor hypofunction upregulates the expression of immediate early genes in several VTX-2337 regions [39], [40]. Consistent with this finding, we demonstrated that MK-801 increased the number of c-Fos-positive cells in the PVN and PC/RS (Fig. 5). Importantly, the MK-
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Cubic equations of state CEoS are particularly
2019-07-08
Cubic equations of state (CEoS) are particularly popular due to their simplicity and relatively good accuracy in predicting vapour-liquid equilibrium and liquid-liquid equilibrium for small, non-polar, non-associating molecules, such as light hydrocarbons. CEoS can match the phase boundaries (L/LL a
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NECA what In some of our studies we examined the
2019-07-08
In some of our studies we examined the occurrence of ERβ and SHBG and a possible colocalization between them. Fig. 5 shows that there is no big difference in the occurence of ERβ after short time (A) as well as long time (B) treatment with E2. We can find the receptor at the cell membrane as well as
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br Material and methods br
2019-07-08
Material and methods Results Discussion Isolated proton pump inhibitors list have several potential advantages over other in-vitro approaches, such as expression of properties similar to their site of origin including the possibility of bidirectional transmembrane transport and exposure. Fu
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In conclusion we have discovered two new derivatives
2019-07-08
In conclusion, we have discovered two new derivatives ( and ) that are potent inhibitors of DHODH. H and C NMR spectroscopic data revealed that these compounds undergo ready isomerisation at room temperature in -DMSO, but the docking studies indicate that there is neither conformation nor configurat
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The methods used for cytokine analysis such as ELISA or
2019-07-08
The methods used for cytokine analysis, such as ELISA or multiplex systems could also influence the concentrations of cytokines analysed. It is therefore crucial to use the same lot of the multiplex analysis kit to make such a comparison [21]. In our study, we ensured that the analysis was performed
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br Oxidoreductase like MEM for prodrug
2019-07-05
Oxidoreductase-like MEM for prodrug activation Future outlook Although MEM-mediated prodrug activation has been performed by different MEMs and prodrugs, and their effectiveness have been proved in vivo, only a few types of MEMs or prodrugs have been explored in prodrug activation until now [2
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br Acknowledgments br Introduction Ubiquitin
2019-07-05
Acknowledgments Introduction Ubiquitin ligases limit the stability and activity of substrates by targeting them for proteasomal-dependent degradation. Siah is a two-member family of ubiquitin ligases implicated in control of key cellular processes. Among those, Siah ligases control prolyl hydr
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br Introduction Vitis vinifera L is one of the
2019-07-05
Introduction Vitis vinifera L. is one of the most worldwide-grown fruit crop and is mostly used in the wine industry (Bouquet, 2011). Domestication and history changed dramatically the biology of this species and today there are thousands of V. vinifera varieties, being many of them closely relat
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br Conclusions Overexpression of DDR might
2019-07-05
Conclusions Overexpression of DDR2 might contribute to tumor progression in lung SQCC, and the T681I mutation we found in this work is an inactivating mutation. There is a possibility that not only activating mutation but also overexpression of DDR2 might be a molecular target for treatment of lu
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To date little is known about the regulation of
2019-07-05
To date, little is known about the regulation of PCD through phytocystatin inhibitory activity. Inhibitors that may regulate leaf senescence (Huang et al., 2001, Tajima et al., 2011) or may inhibit PCD induced by abiotic factors, such as mechanical tissue damage or oxidative stress caused by cold (B
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