• An emergency decompressive craniectomy of the right fronto t

  2018-11-12

  

  An emergency decompressive craniectomy of the right fronto-temporo-parietal region was performed, and an external ventricular drain was placed. The tumor was dark-brown, lobulated, and hypervascular. The interface between cyclosporin and tumor was well defined. The tumor and its dural attachment wer

• br Regulation of Nrf activation The core of

  2018-11-12

  

  Regulation of Nrf2 activation The core of the Nrf2 regulation is Keap1. Keap1 functions as a negative regulator of Nrf2 by promoting ubiquitination and proteasomal degradation of Nrf2 [15]. Since Keap1 has highly reactive sulfhydryl groups in its cysteine residues, it is considered as a sensor fo

• br Energy absorption and metabolic

  2018-11-12

  

  Energy MK0752 and metabolic homeostasis Because of an increase in the number of diseases caused by overnutrition, several studies have focused on the relationship between energy intake and balanced metabolism and health. After the absorption of energy substances such as glucose, the body first ac

• There are many studies on antioxidant activity of A

  2018-11-12

  

  There are many studies on antioxidant activity of A. calamus for instance, the ethanolic extract prevented acrylamide-induced hind limb paralysis, decreased GSH and GST, increased dopamine receptors in the corpus striatum [37]. Ethyl acetate and methanolic extracts (50mg/kg bw) of A. calamus was eff

• br Conclusions Sitosterol d glucoside and

  2018-11-12

  

  Conclusions β-Sitosterol-d-glucoside (1) and five condensed tannin fractions (2, 3, 4, 5, and 6) were isolated from the leaves of Q. phillyraeoides. The α-glucosidase inhibitory and antioxidant activities of the isolated constituents were investigated. Four antioxidant assays were successfully co

• The expression of germ line

  2018-11-12

  

  The expression of germ-line-specific genes was also detected in the putative EGC, showing a consistent increase compared with pFF. All of our analyzed PGC-derived cell lines expressed BLIMP1 during the entire period of culture (over 10 passages), even in the presence of bFGF at concentrations as hig

• Several pancreatic cancer cell lines and human tissue

  2018-11-12

  

  Several pancreatic cancer cell lines and human tissue samples were surveyed for cell surface, intracellular, and functional markers. CD20, CD24, CD44, CD133, CD184 (CXCR4), CD326 (EpCam), Sox-2, and OCT3/4 were examined in established pancreatic cancer cell lines. The functional marker, i.e., SP, wa

• As with many biological phenomena immunomodulation is a doub

  2018-11-12

  

  As with many biological phenomena, immunomodulation is a double-edged sword, and many of these tolerogenic mechanisms appear to be manipulated by cancer csf-1r to create an immunoprivileged niche to further their own growth (Rabinovich et al., 2007). One of the most prominent immunomodulatory leuko

• In our model DNA damage forces

  2018-11-12

  

  In our model, DNA damage forces cells into cellular senescence, whereas ATM-dependent and p53-antagonized cytokine secretion activates BMP2/JAK-STAT signaling and stimulates the differentiation process in a progressive feed-forward manner. This senescent state is very different from the GFAP-associa

• Acknowledgments We are indebted to the Citomics unit of the

  2018-11-12

  

  Acknowledgments We are indebted to the Citomics unit of the IDIBAPS for technical help. This work was supported by grants from the Spanish Ministry of Economia y CompetitividadBIO2011-30299-C02-02 and from CIDEM-Generalitat de CatalunyaVALTEC09-2-0047. and was developed at the Centro Esther Koplowi

• On the other hand with the

  2018-11-12

  

  On the other hand, with the present study we verified that METH did not alter protein expression of cyclin inhibitors, p21 and p27, which suggests the involvement of other mechanisms in METH-induced cyclin E down-regulation. In fact, Heo et al. (2006) showed that blockade of MAPK pathway with PD-980

• Peripheral blood mononuclear cells PBMCs were obtained from

  2018-11-12

  

  Peripheral blood mononuclear Phenyl sulfate (PBMCs) were obtained from a 43-year-old male with familial HCM. The patient fulfilled clinical criteria for HCM with a maximum left ventricular wall thickness of 28mm (normal 7–10mm) in the absence of loading conditions. The patient is heterozygous for t

• Immunocytochemistry Cells were fixed at room temperature wit

  2018-11-12

  

  Immunocytochemistry. Cells were fixed at room temperature with 4% paraformaldehyde for 10min. Non-specific proteins were blocked by ultra V block (Thermo). The cells were then treated with primary AZD7762 overnight at 4°C. Primary antibodies were against TRA-1-60 (1:500, MA1-023, Thermo Fisher), OC

• Importantly expression of SMA is not simply a marker for

  2018-11-09

  

  Importantly, expression of α-SMA is not simply a marker for MF activation, but also the driver of cell function and fate. Increased expression of α-SMA directly reduces the clonal potential of hMSCs and guides their differentiation toward osteoblasts. Hence, α-SMA not only identifies osteoprogenitor

• The nuclear factor kappa B

  2018-11-09

  

  The nuclear factor kappa B (NF-κB) is known for its key role in the regulation of many cellular processes. The classical NF-κB is a heterodimer of p50 and p65/RelA proteins, in which the p65/RelA subunit has transactivation activity. The IκB kinase (IKK) complex mediates the degradation of IκBs to a

15515 records 1013/1035 page Previous Next First page 上5页 10111012101310141015 下5页 Last page