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br Materials and methods br Results br Discussion br
2023-08-15
Materials and methods Results Discussion Conclusions These studies provide important mechanistic insights to explain the long-established physiological observation that obese adipose tissue has higher rates of basal lipolysis. Increased lipolysis contributes to increased hepatic D-erythr
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ADORs accomplish a variety of physiological effects
2023-08-15
ADORs accomplish a variety of physiological effects in different tissues. In neurons, ADORs regulate the release of neurotransmitters such as dopamine and glutamate (Ferré et al., 1992; Fredholm and Dunwiddie, 1988; Ginsborg and Hirst, 1972; Gonçalves et al., 2015; Quarta et al., 2004; Stella et al.
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br Experiment br Results and discussion br Conclusion
2023-08-15
Experiment Results and discussion Conclusion Introduction Tuberculosis (TB) is a chronic specific bacterial infection caused by bacteria of the Mycobacterium tuberculosis [1]. TB remains one of the deadliest diseases in the world. It is the second leading infectious cause of death after
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Acetylcholinesterase AChE activity and expression level can
2023-08-15
Acetylcholinesterase (AChE) activity and expression level can be down regulated by TCDD in neuronal cells [3], [6]. Thus AChE could be considered as a target of the neuronal toxicity of dioxin. AChE has several types of transcripts by alternative splicing in the 3′ region of primary transcripts [7],
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rs G allele was previously associated with a
2023-08-15
rs523349 G allele was previously associated with a decrease in the conversion rate of testosterone to DHT (Beesley et al., 2007). This SRDA52 variant may have a trend towards higher testosterone availability, which according to the US Food and Drug Administration is described as a teratogen of categ
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br Materials and methods br Results
2023-08-14
Materials and methods Results Discussion I/R injury is characterized by myocardial damage triggered by the ischemic insult followed by reperfusion injury. While the primary insult depends mainly on the severity and duration of blood flow restriction and the breakdown of ATP-dependent beta-N
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Researchers demonstrated that mitochondria are the main prod
2023-08-14
Researchers demonstrated that mitochondria are the main producers of ROS and are the most sensitive to the effects of ROS. Mitochondria-mediated apoptosis may not be limited to the role of cytochrome c in the activation of caspase-3 and ROS may provide an alternate mitochondrial signaling pathway (H
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CORT induced hippocampal damage has been implicated in
2023-08-14
CORT-induced hippocampal damage has been implicated in depression, aging and long-term glucocorticoid therapy. Therefore, finding a drug that can protect hippocampal neurons from the adverse effects of CORT could have significant clinical benefits. In this regard, we tested the potential protective
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br Results br Discussion Here we uncovered a role
2023-08-14
Results Discussion Here, we uncovered a role for Wnt-Fz7 signaling in LTP-dependent spine plasticity and synaptic localization of AMPARs. We demonstrated that LTP induction increased Wnt7a/b protein at ddhUTP and spines. Direct blockade of endogenous Wnts impaired LTP-mediated structural spin
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br Materials and methods br Results
2023-08-14
Materials and methods Results Discussion Prostate cancer is the most common cancer in men in the United States and the second leading cause of cancer death. Therapeutic interventions include mainly: radical prostatectomy or radiation therapy (RT), with or without androgen deprivation therap
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iso 1 mg There are two ways to transport FFAs into cells
2023-08-14
There are two ways to transport FFAs into cells. First by passive diffusion. Second as the putative long-chain fatty iso 1 mg transporters are proposed, CD36 the plasma membrane-associated fatty acid-binding protein (FABPpm) and fatty acid transport proteins (FATP) [11], where CD36 is responsible f
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br Introduction br Rac dependent
2023-08-14
Introduction Rac1-dependent ROS and Koumine regulation in neuronal functions NOX-mediated ROS have an important role as physiological messengers. One remarkable example regarding such a function is during axonal formation. In this line, increased p40phox/NOX2 levels and co-localization at grow
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Princen Panier specifically address the
2023-08-14
Princen, 2012, Panier, 2013 specifically address the issue of ACE using the commercial database AMADEUS. However, both studies focus only on corporate leverage and the ACE in Belgium. Due to the lack of a counterfactual, these authors consider firms in other European countries, e.g., France, as a co
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In summary we could identify and experimentally
2023-08-14
In summary, we could identify and experimentally confirm two novel SBEs within the 5-LO promoter and we were able to demonstrate that TGFβ and SMADs stimulate 5-LO promoter activity. Moreover, an elevated 5-LO expression has been linked to different forms of leukaemia. Therefore, the influence of ML
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br Conclusion In this brief Letter
2023-08-14
Conclusion In this brief Letter, we report an easy method for the preparation of the antileukemic natural product 1. Using a biomimetic strategy,1, 8 in which the aromatic residues are attached to a lysine moiety prior to the reduction of the central carboxylate group, a step-economical synthesis
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