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br Acknowledgements The authors have no ethical conflicts to
2022-08-03
Acknowledgements The authors have no ethical conflicts to disclose. The authors have no conflicts of interest to declare. This work was funded by the Research Council of Lithuania. Introduction This paper studies whether there is a causal influence of the risk-taking incentives provided by op
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In the course of an internal FAAH program many very
2022-08-03
In the course of an internal FAAH, program,, , , , , , , , , , , , , many very similar compounds were profiled in vivo with particular interest paid to their ability to penetrate the BBB. The compounds profiled were heteroaryl piperazinyl and piperadinyl ureas; a class of compounds, reported on pr
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It is well known that TLR
2022-08-03
It is well known that TLR4-induced inflammation is associated with behavioural alterations including fever, hypolocomotion, altered appetite, anxiety and anhedonia (Dantzer, 2006, Dantzer et al., 2008). The current data demonstrate that while PF3845 potently attenuates TLR4-induced cytokines in the
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Mammals have three known Gli proteins Gli and
2022-08-03
Mammals have three known Gli proteins: Gli-1, -2 and -3. Gli-1 does not undergo proteosomal degradation and hence, remains untruncated and always acts as a transcription promoter. Gli-1 is an important target gene for Gli-2. Full-length Gli-2 accumulates when Smo is activated because activated Smo p
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br Acknowledgements We thank the support of the
2022-08-02
Acknowledgements We thank the support of the National Natural Science Foundation of China (NSFC) project 81501342 and support from the Disciplinary Group of Oncology and Immunology program of Xinxiang Medical University. Introduction First described as a new clinical entity in 1981, the Acqui
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br Material and methods br
2022-08-02
Material and methods Results Discussion Organisms have developed a variety of anti-glycation defense mechanisms. In Diclazuril to the aldose-reductase-pathway or 2-oxoaldehyde dehydrogenase-pathway, the glyoxalase system is the only mechanism, which is not restricted to liver [19]. This sy
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The soluble receptor for advanced glycation end
2022-08-02
The soluble receptor for advanced glycation end products has been already studied in physiological and pathological pregnancy. In accordance to our previous studies we showed increased sRAGE serum levels in women with threatening premature labor [15] and we described a negative correlation of sRAGE
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br Materials and methods br Results
2022-08-02
Materials and methods Results Discussion Heart hypertrophy is initially physiological to compensate for the loss of heart functions. However, sustained stresses lead to a pathological status, in which myocardium becomes stiffened by interstitial fibrosis and thereby diastolic dysfunction in
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Rifabutin receptor br Methods GLUT DS was diagnosed either w
2022-08-02
Methods GLUT1DS was diagnosed either when analysis of the SLC2A1 gene showed a pathogenic mutation and/or when cerebrospinal fluid (CSF) analysis met the criteria for GLUT1DS: a CSF Rifabutin receptor below the 10th percentile, a cerebrospinal fluid (CSF) to blood ratio below the 25th percentile
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br Genetic rescue of GluR A dependent
2022-08-02
Genetic rescue of GluR-A-dependent spatial working memory Spatial working memory performance in GluR-A−/− mice can be restored by the forebrain-specific IFN-gamma, murine recombinant of GluR-A subunits labeled with green-fluorescent protein (GFP) on an otherwise GluR-A knockout background (Schmit
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Acknowledgments br Introduction The gut derived hormone oxyn
2022-08-02
Acknowledgments Introduction The gut-derived hormone oxyntomodulin (OXM) is a naturally occurring dual agonist of both the glucagon receptor (GCGr) and glucagons-like peptide 1 receptor (GLP-1r). Structurally OXM is the 29 hyPerFUsion™ high-fidelity DNA polymerase of glucagon with a C-terminal
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Interruption of glucagon signaling pathway targeting glucago
2022-08-02
Interruption of glucagon signaling pathway targeting glucagon receptor (GCGR) by gene knockout, antisense oligonucleotides or specific antagonists induces α-cell hyperplasia and alleviates hyperglycemia and other metabolic symptoms in diabetic animals and patients [[7], [8], [9]]. Here we used a ful
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br Conclusion In the present study we
2022-08-02
Conclusion In the present study, we found that the majority of commercially available antibodies and antibody-based tools against galanin and its receptors that we tested do not meet validation requirements. Therefore, critical validation of these tools by the user is essential before being used
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Having shown that some of substitutions Cl CF
2022-08-02
Having shown that some of substitutions (Cl, CF) at the 2-position of the thiophene improved rat microsomal stability, and polar groups at the 4-position of the aryl ring had a beneficial effect on stability in both human and rat microsomes, we combined these features in a new set of analogs. Methyl
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84 9 br Introduction Histamine stored in mast cells and baso
2022-08-01
Introduction Histamine stored in mast cells and basophils has been recognized as one of the most critical mediators in allergic reactions and plays an important role in eliciting the nasal symptoms of allergic rhinitis, such as sneezing, nasal itch, pain, rhinorrhea, and congestion [1], [2]. It i
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