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br Pharmacological anti aging approaches and the Hippo pathw
2021-12-14
Pharmacological anti-aging approaches and the Hippo pathway Aging and age-related pathologies are the main causes of disabilities and death. As Magalhañes and colleagues suggest, the challenges of developing anti-aging pharmacological therapies may, in part, be due to the complexity of aging mole
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Anti apoptotic Bcl proteins have
2021-12-14
Anti-apoptotic Bcl-2 proteins have become attractive targets for anti-cancer agents development, because they are associated with progression of a wide variety of human cancers., , The small-molecular Bcl-2 inhibitor venetoclax (ABT-199) () has been approved recently for the treatment of patients wi
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Racemic protein crystallography has been proven to
2021-12-14
Racemic protein crystallography has been proven to be a powerful technique for crystallizing proteins , , , , . The structures of many difficult-to-crystallize peptides/proteins of different sizes were resolved by the racemic protein crystallography combined with the protein chemical synthesis , , ,
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DNA methylation is a kind of epigenetic modifications that c
2021-12-14
DNA methylation is a kind of epigenetic modifications that can be described as a heritable alteration in gene expression, without any changes in the DNA sequence. Recent evidences suggest that the regulation of DNA methylation status is a frequent and early event in prostate carcinogenesis. For exam
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Ikaros utilizes chromatin remodeling to activate or repress
2021-12-14
Ikaros utilizes Imipenem remodeling to activate or repress the transcription of its target genes (Su et al., 2004). Ikaros directly associates with histone deacetylases HDAC1 and HDAC2 and can recruit them to the upstream regulatory elements of its target genes (Kim et al., 1999, Koipally et al., 1
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br Material and methods br Results
2021-12-14
Material and methods Results The search for proteins selectively expressed in pancreatic islet molecular weight to moles in the Human Protein Atlas (HPA) yielded 27 hits, including well-known islet cell markers such as insulin, glucagon and pancreatic polypeptide (Table 1). The search algorit
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The results of our study indicate the general
2021-12-14
The results of our study indicate the general importance of the gp120 V3 loop mtor inhibitors patch in the subunit association of primate immunodeficiency virus Env trimers. Our observation that the stem insertion mutants and hydrophobic patch mutants exhibit similar phenotypes with respect to gp12
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br Conclusion The wild study
2021-12-14
Conclusion The wild study reports seasonal variations in reproductive physiology, behavior and hedgehog inhibitor plasticity at different age stages in wild-caught Mongolian gerbils. The gerbils in breeding seasons have more mature sexual development, higher exploratory behavior, higher novelty
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Our inhibitor studies revealed the presence of a signaling
2021-12-14
Our inhibitor studies revealed the presence of a signaling network triggered by dicarbonyl stress. Nevertheless, p38-MAPK activation was clearly necessary for NADPH-oxidase mediated production of ROS. This is consistent with data from other groups using different cell culture systems [37], [38], [39
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methylguanine dna methyltransferase br Regulation of Glu tra
2021-12-14
Regulation of Glu transporters The pivotal role of Glu transporters in the fine tuning and turnover of this excitatory amino methylguanine dna methyltransferase calls for a detailed characterization of its regulation. Several general mechanisms that modify Glu uptake activity have been described.
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FFAR is highly expressed not only
2021-12-14
FFAR1 is highly expressed not only in β cells but also in α aspirin solubility australia (Segerstolpe et al., 2016), which gives the interesting perspective that 20-HETE may function both as an autocrine and as a paracrine regulator of islet cell function (Figure 1A), i.e., acting in symphony with
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Young et al described the role of adenine monophosphate
2021-12-14
Young et al. [40] described the role of adenine monophosphate-activated protein kinase (AMPK) in the translocation of GLUT4 in the heart. The AMPK is activated during muscle contraction [74] by converting AMP to ATP. The adenosine analog, 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR), is a c
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CH 223191 receptor One major mode of bioelectric action is t
2021-12-14
(2) One major mode of bioelectric action is that of an amplifier of subcellular symmetry-breaking mechanisms into tissue-wide order. An example is the patterning of the embryonic left (L)-right (R) axis reviewed in References [57, 58]; the following scheme describes the data obtained largely from th
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The active site of PS
2021-12-14
The active site of PS1 is located at the interior of its TM horseshoe-like fold (29) (Fig. 1). TM2 and TM6 serve as “doors” for substrate entry (30), as also observed in recent molecular dynamics (MD) simulations of the PS1 subunit (31). Recent coarse-grained (CG) and atomic simulations also showed
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The absence of differences between GalR knockout
2021-12-14
The absence of differences between GalR1 knockout and wild type mice in kainic acid-induced seizures suggests that GalR1 do not interfere with the seizure-inducing action of kainic acid. Postsynaptic kainate receptors are excitatory ionotropic glutamate receptors and their activation leads to seizur
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