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TGF sign http www cy nhs ester
2018-10-23
TGF-β signaling is critical for differentiation and survival of SMCs from NCSCs and for maintaining the contractile phenotype late in life (Humphrey et al., 2014; Mao et al., 2012; Xie et al., 2013). In NCSCs, p-Smad2 interacts with the myocardin-related transcription factor to regulate SMC marker g
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Metabonomic alterations as a result
2018-10-23
Metabonomic alterations as a result of antibiotic use are important in the context of CDI (Theriot et al., 2014). As an example, primary and secondary bile acids have markedly different effects on C. difficile; primary bile acids promote growth of this pathogen while secondary bile acids are inhibit
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Here we sought to characterize
2018-10-23
Here we sought to characterize the contribution of DGKα and DGKζ to the generation of non-conventional bystander memory-like CD8+ T cell populations. We show that DGKζ deficiency, but not that of DGKα leads to increased output of CD44hiCD122hi CD8+ T keap1-nrf2 pathway and facilitates IL-2 and IL-1
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Furthermore whilst DNA sequencing provides an extended
2018-10-23
Furthermore, whilst DNA sequencing provides an extended view of the microbiome, it is limited in providing information on “which microorganisms” maybe directly contributing to infection. This is increasingly important when analysing our data set where regardless of the spectrum of activity of antimi
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Almost any drug is eventually found to have off target
2018-10-23
Almost any drug is eventually found to have off-target effects, beyond effects anticipated based on knowledge about their presumed targets. To prove that putative senolytic drugs actually cause alleviation of phenotypes through eliminating senescent ubiquitin e3 ligase in vivo over and above any off
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br Data experimental design materials and methods
2018-10-23
Data, experimental design, materials and methods Boron (B)-tolerant ‘Xuegan’ (Citrus sinensis) and B-intolerant ‘Sour pummelo’ (Citrus grandis) seedlings were used to investigate the effects of B-toxicity on leaf proteomics. Plant culture and B treatments were performed as described previously [1
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br Data A summary of the main
2018-10-23
Data A summary of the main information regarding number of search inputs, PSMs, peptide IDs, and protein IDs is reported in Table 1. As it is possible to observe, for one of the samples only two SCX fractions were obtained. For this sample the amount of apoplastic proteins that were retrieved fro
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br Acknowledgments br Data The
2018-10-23
Acknowledgments Data The dataset of this paper provides additional information to Ref. [1]. The rear surface passivation quality in relation to the ALD Al2O3 processing parameters is reported in Figs. 1–5, the PERC cell properties are reported in Figs. 6–8 and Table 1, and the metal contact de
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La subordinaci n adaptada no
2018-10-22
La subordinación adaptada no emerge de forma azarosa; su proceso de construcción y apropiación en las mujeres está fuertemente determinada por las representaciones que sustentan la misma cultura, regulada por un sistema de dominación masculina. La antropóloga Michelle Zimbalist (1979) efectuó estudi
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As pues un punto de partida en estos
2018-10-22
Así pues, un punto de partida en estos debates es que la percepción AZD4547 través de los sentidos corporales está mediada social y culturalmente. Dicho supuesto emerge del viraje al estudio sociocultural de los sentidos en ciencias sociales y de ciertas condiciones de posibilidad, tanto disciplinar
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On the other hand controlling shareholders can elect their
2018-10-22
On the other hand, controlling shareholders can elect their representative(s) to the board of directors who will appoint a manager that will act in their self-interest. Jensen and Meckling (1976) and Shleifer and Vishny (1986) demonstrate that controlling shareholders can impose greater monitoring
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Part II of this study addresses the
2018-10-22
Part II of this additional hints study addresses the design in a supposed operationalization phase that was guided by both data sets of Part I. Furthermore, the data were used to develop a checklist for architects. The design was based on the joint description of a fictional persona by two of the a
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In fact in the th century
2018-10-22
In fact, in the 17th century craftsmen in Roussilon area of South France developed a type of flat vault, so called Roussilon Vault, to be used in both public and private buildings. These vaults were built of one or more layers of thin tiles laid in quick-setting plaster mortar on a movable centering
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From the data here midline crossing tumor p and
2018-10-22
From the data here, midline-crossing tumor (p=0.0208) and voltage gated potassium channel floor invasion (p=0.0196) are significantly related to the presence of cN2c and pN2c. This is consistent with other studies. All pN2c patients were histopathologic and had clinically advanced tumor stage (≥T3)
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br mtDNA mutation in human cancers Several
2018-10-22
mtDNA mutation in human cancers Several authors have evaluated not only the quantitative change in mtDNA copy number, but also the qualitative mtDNA D-loop mutations in human cancers. D-loop mutations, including the D310 region, have been reported in prostate cancer, head and neck cancer, lung ca
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