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The following are the supplementary data
2020-08-10
The following are the supplementary data related to this article. Acknowledgments Introduction Cyclooxygenases metabolize arachidonic Picrotoxin to five primary prostanoids, PGE2, PGF2, PGI2, TXA2 (TX), and PGD2. These lipid mediators interact with specific members of a family of distinct G-p
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In summary the metabolism of
2020-08-10
In summary, the metabolism of GEF in HLM and MLM was extensively studied using a LC–MS-based metabolomic approach. This study identified a total of 34 metabolites and adducts related to GEF (Fig. 10) and identified three new potential reactive metabolites, including two aldehydes and one iminium. Pr
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Crystallographic and NMR based analyses have revealed
2020-08-10
Crystallographic and NMR-based analyses have revealed that RINGs and U-boxes have a common mode of interaction with E2s (Fig. 2A). The key structural elements are two loop-like regions, which, in the case of RINGs, coordinate Zn. The loops surround a shallow groove formed by the central α-helix. Tog
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Cx platin could improve the level of
2020-08-08
Cx-platin could improve the level of cellular uptake and DNA platination, hence triggering distinct DNA damage repair pathways. The data (Fig. 3B, C and D) demonstrated that Cx-platin could increase the foci number of γH2AX in cancer cells, preventing the efficient DSBs repair. This gives a good exp
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Imaging of primary Tfh cells at the peak of the
2020-08-08
Imaging of primary Tfh cells at the peak of the GC response revealed clear spatial segregation in the FM and GC compartments. This confinement was confirmed by TPP and discontinuous cell tracking 24 hr later, which showed retention of the majority of photoconverted GC Tfh cells in the original GC an
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br Experimental Procedures br Acknowledgments We thank R Bri
2020-08-08
Experimental Procedures Acknowledgments We thank R. Brink for providing HEL2x, M. Tanaka for CD169DTR mice, R. Lathe for making Cyp7b1+/− mice available, and M. Barnes and A. Reboldi for comments on the manuscript. T.Y. is an Irvington Institute Postdoctoral Fellow at the Cancer Research Insti
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Human CRBN has amino acid residues in three
2020-08-08
Human CRBN has 442 amino trabectedin residues in three regions, an N-terminal extension, Lon domain and cereblon domain of unknown activity, binding cellular ligands and thalidomide (CULT) domain. The domains have 79, 238, and 125 residues respectively. The N-terminus is disordered for the first 30
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CSN is a conserved typically eight subunit multiprotein comp
2020-08-08
CSN is a conserved, (typically) eight subunit multiprotein complex composed of six PCI (proteasome lid, CSN, WAY 316606 factor 3) subunits (CSN1–CSN4, CSN7 and CSN8) and two MPN (MPR1/PAD1 amino-terminal) domain-containing subunits (CSN5 and CSN6). Cullin deneddylation is specifically mediated by C
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Understanding the nature of protein collagen interactions is
2020-08-07
Understanding the nature of protein–collagen interactions is also crucial in developing biomaterials that replicate the structural and biological characteristics of collagen [140]. These biomaterials can then be applied to develop scaffolds or tissues that can be valuable in surgeries or medicine [7
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One of the proteins DNA PK interacts with and
2020-08-07
One of the proteins DNA-PK interacts with and phosphorylates is HSP90α (Lees-Miller and Anderson, 1989), one of the two isoforms of HSP90 (α and β). HSP90 is unique among chaperone proteins in that it binds to and folds only a small fraction of the total proteome, called “clients,” the majority of w
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From Figure it appears that TdT has lost just the
2020-08-07
From Figure 1, it appears that TdT has lost just the 5′ phosphate binding site of pol mu and that its Loop1 is of the same length, but with a different sequence. Regarding Loop1 and its vexing property of escaping structural characterization in pol mu, we expect that the structure of the TdT chimera
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Z-DEVD-AFC However the recombinant strains developed in the
2020-08-07
However, the recombinant strains developed in the above studies were devoid of system of regenerating NADH by the Z-DEVD-AFC themselves even though sufficient supply of NADH is required for the activity of XDH during bioconversion of xylulose to xylitol. It has resulted the requirement of adding a
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The brain is an important
2020-08-06
The Hydrocortisone is an important target organ for exogenous stimulation, including DBP (Wójtowicz et al., 2017), while the hippocampus is a key functional region for learning and memory (Whitlock et al., 2006). There is emerging evidence that phthalate including DBP may have deleterious effects o
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Death associated protein kinase DAPK a
2020-08-06
Death-associated protein kinase (DAPK), a known apoptosis regulator, is shown to be up-regulated in atherosclerotic lesions (Arab et al., 2008). DAPK up-regulation leads to increased cell turnover and arterial wall instability, which provides increase susceptibility to LDL DPP4 Activity Fluorometric
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In this work we provide evidence for the interconnection bet
2020-08-06
In this work we provide evidence for the interconnection between CRM1-dependent nuclear export and translation of the HIV-1 unspliced mRNA, two processes previously shown to require the catalytic activity of DDX3 [3], [6]. This occurs through the intrinsically disordered N-terminal domain of DDX3, w
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