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The efficacy of antibiotics in improving smell
2024-01-03
The efficacy of AZD 0530 in improving smell function has been previously found to be negative, both when used for bacterial and viral infections. Van Zele et al, in a double-blind, placebo-controlled, multicenter study, found no influence of doxycycline treatment on self-reported olfactory loss in
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br Diabetic retinopathy Diabetic retinopathy is a severe sig
2024-01-03
Diabetic retinopathy Diabetic retinopathy is a severe sight-threatening complication associated with diabetes mellitus. It is one of the most common causes of preventable blindness in the world. The risk of developing microvascular diabetic complications increases in diabetic patients with an inc
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Introduction Cardiovascular disease is the principal cause o
2024-01-03
Introduction Cardiovascular disease is the principal cause of morbidity and mortality in patients with Apoptozole (1). Comprehensive management of these patients includes not only adequate glycemic control but also attention to additional recognized risk factors. Hypertension is a cardiovascular ri
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E64 Recent work has detailed the impact of genetic deletion
2024-01-03
Recent work has detailed the impact of genetic E64 of AMPK in the liver, revealing only minor phenotypes upon removal in mice (Boudaba et al., 2018). However, these studies very elegantly showed the potential for small molecule-mediated activation of AMPK to elicit large changes in lipid metabolism
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Although it is not known if CP AMPAR regulation
2024-01-03
Although it is not known if CP-AMPAR regulation is required for LTD, our previous characterization of AKAP150ΔPIX knockin mice that are selectively deficient in CaN anchoring, due to disruption of a PxIxIT-type CaN docking motif, provided important insights. We found that AKAP-CaN signaling dephosph
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br Discussion The patient presented initially only
2024-01-03
Discussion The patient presented initially only with parietal symptoms in the form of acalculia, visuo-spatial deficits, and visuo-perceptual deficits and dressing apraxia. He also had simultognosia as early symptoms. Later when the disease progressed he had recent memory deficits and language in
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Liaohe River situates in the southwestern part of Northeast
2024-01-03
Liaohe River situates in the southwestern part of Northeast China and flows through Liaoning Province. Due to the rapid urbanization and industrialization, Liaohe River has become one of the most polluted rivers in China. Multitudinous organic pollutants that can induce toxicity to organisms such as
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There are two ways to transport FFAs into
2024-01-03
There are two ways to transport FFAs into cells. First by passive diffusion. Second as the putative long-chain fatty a83 01 transporters are proposed, CD36 the plasma membrane-associated fatty acid-binding protein (FABPpm) and fatty acid transport proteins (FATP) [11], where CD36 is responsible for
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There are two ways to transport FFAs into
2024-01-03
There are two ways to transport FFAs into cells. First by passive diffusion. Second as the putative long-chain fatty atm kinase inhibitor transporters are proposed, CD36 the plasma membrane-associated fatty acid-binding protein (FABPpm) and fatty acid transport proteins (FATP) [11], where CD36 is re
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br ACK signaling partners ACK interacts with
2024-01-03
ACK1 signaling partners ACK1 interacts with and tyrosine phosphorylates many cellular proteins regulating critical cellular processes [11]. While ACK1 shares common intracellular effectors such as AKT with other signaling pathways, it imparts specificity to signaling by phosphorylating effectors
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HT modulates cortical and hippocampal pyramidal cell
2024-01-02
5-HT modulates cortical and hippocampal pyramidal cell function in a very complex manner, since most 5-HT receptor subtypes (excitatory as well as inhibitory) are expressed on pyramidal fgfr1 as well as GABAergic interneurons that exert inhibitory control over pyramidal cells (Leiser et al., 2015, D
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HT modulates cortical and hippocampal pyramidal cell
2024-01-02
5-HT modulates cortical and hippocampal pyramidal cell function in a very complex manner, since most 5-HT receptor subtypes (excitatory as well as inhibitory) are expressed on pyramidal 4-iodo-SAHA as well as GABAergic interneurons that exert inhibitory control over pyramidal cells (Leiser et al.,
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For the NSCLC patients with EGFR activating mutations EGFR
2024-01-02
For the NSCLC patients with EGFR-activating mutations, EGFR-TKIs (gefitinib and erlotinib) are effective clinical therapies [21], [22]. However, approximately 10% of patients harboring EGFR-sensitizing mutations exhibit intrinsic resistance, and up to 40% do not attain a major response to treatment
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Additionally in a previous transgenic model with
2024-01-02
Additionally, in a previous transgenic model with autotaxin under the control of the MMTV-LTR promoter, aberrant expression of human autotaxin caused late-onset, metastatic breast cancer [5]. The AT-ATX transgenic model is analogous to the previous one because ∼30% of all spontaneous tumors appeared
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Treatment of RAW cells with AP exosomes caused an increase
2024-01-02
Treatment of RAW264.7 membrane transporter with AP(+)-exosomes caused an increase in their phagocytic activity. In the presence of amastatin, phagocytic activity was not completely suppressed, suggesting that at least two components were responsible for the activity; one of which is aminopeptidase(s
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