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The most significant finding in these studies was
2018-11-08
The most significant finding in these studies was the 10-fold enhanced expansion of transplantable HSCs in mice engrafted with IK6-transduced human CD34+ CB cells. This was indicated both by the higher numbers of CD34+CD38− Decitabine Supplier regenerated from the IK6-transduced cells after 6 month
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A key element of the culture
2018-11-08
A key element of the culture conditions is the balanced combination of growth factors and signaling molecules (e.g., EGF, bFGF, IGF, insulin, transferrin, and Rock inhibitor), which apparently generates an artificial androgen-independent PESC microenvironment that promotes the self-renewal and maint
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Treatment options for xerostomia include administration of s
2018-11-08
Treatment options for xerostomia include administration of saliva substitutes or stimulants (Fox, 2004). Saliva substitutes might improve some, but not all, problems associated with SG dysfunction, whereas stimulants are only useful for people with some remaining SG function. Alternative approaches
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br Results To develop iPSC
2018-11-08
Results To develop iPSC-based model systems of disease, we first prepared a bank of >60 iPSC clones (ten clones per donor; partial set and reprogramming methodology described previously [Mills et al., 2013; Somers et al., 2010]) derived from the dermal fibroblasts of three control individuals wit
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The creation and maintenance of
2018-11-08
The creation and maintenance of subcutaneous patient-derived xenografts (PDX) from fresh or cryopreserved ACC tissue (Moskaluk et al., 2011) provided a renewable source of ACC A 779 manufacturer for validation of our CSC hypothesis. As we previously demonstrated, these PDX models reproduced ACC mor
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br Discussion However it is important
2018-11-08
Discussion However, it is important to note that a number of studies have demonstrated that iPS cell lines derived from skin biopsies typically harbor a unique subset of de novo genetic abnormalities, either in the form of copy-number variation or single base-pair changes (Abyzov et al., 2012; Go
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Generation of new cells during
2018-11-08
Generation of new cells during kidney repair has long been assumed to result from proliferation of surviving terminally differentiated cells. However, much of the modern evidence has used lineage tracing such as Six2 (Humphreys et al., 2008) or a terminally differentiated marker (such as the proxima
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br Results br Discussion The Wnt signaling pathway has
2018-11-08
Results Discussion The Wnt signaling pathway has emerged as the dominant self-renewal pathway for various adult-type stem cells and is required for maintenance of embryonic as well as induced pluripotent stem cells. In the hematopoietic system, only mild increased Wnt dosages result in higher
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Many non integrating reprogramming strategies have been
2018-11-08
Many non-integrating reprogramming strategies have been investigated over the past 8 years, such as minicircle plasmids, synthetic mRNA/miRNA, proteins, and small molecules. However, all these approaches are labor intensive, time consuming, and often inefficient. Recently, much attention has been fo
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Much of our knowledge on DS comes
2018-11-07
Much of our knowledge on DS comes from the documentation of symptoms in patients and analysis of mouse models. Although the contribution of both sources has been crucial in gaining a better understanding of the syndrome, the molecular pathways leading to the development of DS are still largely unkno
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br Conclusion Our findings bolster a prior
2018-11-07
Conclusion Our findings bolster a prior study that reports a positive association between political fragmentation and health disparities (Hutson et al., 2012). We show that Hutson and colleagues’ results have external validity to the 1970s and 1980s, a period in which important, and rapid, change
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Alternatively the notion of peer contagion effects Cohen Pri
2018-11-07
Alternatively, the notion of peer contagion effects (Cohen & Prinstein, 2006; Dishion & Tipsord, 2011) and social mimicry (Moffitt, 1993) place emphasis on the compositional elements of the school environment using socialisation processes to explain similarity in behaviours. Peer contagion effects s
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Although it is currently unclear
2018-11-07
Although it is currently unclear if DNA methylation changes are the cause or the consequence of the disease, it is clear that DNA methylation changes occur early during disease pathogenesis and precede disease detection by histological and/or imaging methods. Several DNA methylation-based biomarkers
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In the publication by Sampath et
2018-11-07
In the publication by Sampath et al. () several lung transplant patients were identified with infections in association with pleuritic, surgical site infection and/or mediastinitis. These findings are unexpected to some degree, as historically has often been dismissed as normal genital flora ().
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Data experimental design materials and methods br
2018-11-07
Data, experimental design, materials and methods Experimental design Two Brassica napus genotype under two kinds of P treatments, long-term low P stress and short-term P-free starvation, were conducted, and three time points were used in each P treatment. Total protein was extracted from roots o
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